Jamie George and Mark Wilson return to the starting line-up as Eddie Jones makes two changes to his England team to take on Wales in Cardiff in Round 3.
George and Wilson both started the opening game of the 2021 Guinness Six Nations against Scotland before being rotated out for the Round 2 victory over Italy but return at hooker and blindside flanker respectively.
As a result, Luke Cowan-Dickie drops to the bench while Courtney Lawes misses out on the matchday 23 entirely after picking up an injury.
The backline for England is unchanged from the 41-18 win against the Azzurri, which means that full-back Elliot Daly will win his 50th England cap and captain Owen Farrell continues at inside centre, with George Ford at No.10.
Young Leicester Tigers forward George Martin could make his international debut at Principality Stadium after being named among the replacements, with Jones again opting for a 6-2 split of forwards to backs on the bench.
Wales are still on course for a Grand Slam after narrowly defeating Ireland and Scotland, both of who were reduced to 14 men, in the first two rounds, while England likely need to win to realistically keep the hopes of defending their Guinness Six Nations title alive.
Head coach Jones said: “Wales is a really special fixture and rivalry. There is a long history between the two nations and the game means a lot to both countries.
“We know we’ll be up against a strong Welsh challenge on Saturday, but we’ve worked really hard in training this week and have got a very good team to face it.
“We want to show people what we are capable of, keep building our performances and the best is yet to come from this England team.”
England team to face Wales in Round 3 of the 2021 Guinness Six Nations 15. Elliot Daly (Saracens, 49 caps) 14. Anthony Watson (Bath Rugby, 48 caps) 13. Henry Slade (Exeter Chiefs, 36 caps) 12. Owen Farrell (Saracens, 90 caps) – captain 11. Jonny May (Gloucester Rugby, 63 caps) 10. George Ford (Leicester Tigers, 74 caps) 9. Ben Youngs (Leicester Tigers, 106 caps) 1. Mako Vunipola (Saracens, 64 caps) 2. Jamie George (Saracens, 56 caps) 3. Kyle Sinckler (Bristol Bears, 41 caps) 4. Maro Itoje (Saracens, 45 caps) 5. Jonny Hill (Exeter Chiefs, 6 caps) 6. Mark Wilson (Newcastle Falcons, 20 caps) 7. Tom Curry (Sale Sharks, 30 caps) 8. Billy Vunipola (Saracens, 58 caps)
Replacements 16. Luke Cowan-Dickie (Exeter Chiefs, 28 caps) 17. Ellis Genge (Leicester Tigers, 25 caps) 18. Will Stuart (Bath Rugby, 10 caps) 19. Charlie Ewels (Bath Rugby, 18 caps) 20. George Martin (Leicester Tigers, uncapped) 21. Ben Earl (Bristol Bears, 10 caps) 22. Dan Robson (Wasps, 9 caps) 23. Max Malins (Bristol Bears, 5 caps)
