There is one change to the starting side that beat Ireland in round four, with Elliot Daly restored to the wing.
Elsewhere, Manu Tuilagi is included in an England match day 23 for the first time since the 2023 Rugby World Cup Bronze Final in Paris, and Ethan Roots returns to the bench.
England XV
15. George Furbank; 14. Tommy Freeman; 13. Henry Slade, 12. Ollie Lawrence; 11. Elliot Daly; 10. George Ford (vc), 9. Alex Mitchell; 1. Ellis Genge (vc), 2. Jamie George (c), 3. Dan Cole; 4. Maro Itoje (vc), 5. George Martin; 6. Ollie Chessum, 7. Sam Underhill, 8. Ben Earl
Replacements
16. Theo Dan, 17. Joe Marler, 18. Will Stuart, 19. Ethan Roots, 20. Alex Dombrandt, 21. Danny Care, 22. Marcus Smith, 23. Manu Tuilagi
