Ollie Lawrence and Will Stuart will make their first Guinness Six Nations starts on Saturday after Eddie Jones named his England side to face Scotland in the Calcutta Cup.
Lawrence will start at inside centre and just outside captain Owen Farrell, who gets the nod at fly-half ahead of George Ford.
Stuart starts at tighthead prop and forms a front row that also includes Jamie George at hooker and Ellis Genge at loosehead.
Maro Itoje and Jonny Hill make up the second row, while Mark Wilson replaces the injured Sam Underhill to complete a back row with Tom Curry and Billy Vunipola.
Ben Youngs will partner Farrell at half-back, Henry Slade will start outside Lawrence in the No.13 jersey and Jonny May, Anthony Watson and Elliot Daly make up the back three.
Prop Beno Obano is in line for his England debut from the bench.
Jones said: “We’re really looking forward to this game and getting the Guinness Six Nations back underway. It’s even more special to be taking part in a 150th anniversary game, it will be a good occasion.
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“It was difficult to pick the 23 players. We’ve had a really good week of training, it’s been very competitive but I’ve gone with what I feel is the strongest 23 for this week.
“The Six Nations is a short tournament, it’s a real sprint so we’ll need to be on the front foot straight away. We know Scotland will be raring to go – but so will we.”
15. Elliot Daly (Saracens, 47 caps) 14. Anthony Watson (Bath Rugby, 46 caps) 13. Henry Slade (Exeter Chiefs, 34 caps) 12. Ollie Lawrence (Worcester Warriors, 3 caps) 11. Jonny May (Gloucester Rugby, 61 caps) 10. Owen Farrell (C) (Saracens, 88 caps) 9. Ben Youngs (Leicester Tigers, 104 caps) 1. Ellis Genge (Leicester Tigers, 23 caps) 2. Jamie George (Saracens, 54 caps) 3. Will Stuart (Bath Rugby, 8 caps) 4. Maro Itoje (Saracens, 43 caps) 5. Jonny Hill (Exeter Chiefs, 4 caps) 6. Mark Wilson (Newcastle Falcons, 19 caps) 7. Tom Curry (Sale Sharks, 28 caps) 8. Billy Vunipola (Saracens, 56 caps)
Replacements
16. Luke Cowan-Dickie (Exeter Chiefs, 26 caps) 17. Beno Obano (Bath Rugby, uncapped) 18. Harry Williams (Exeter Chiefs, 18 caps) 19. Courtney Lawes (Northampton Saints, 85 caps) 20. Ben Earl (Bristol Bears, 8 caps) 21. Dan Robson (Wasps, 7 caps) 22. George Ford (Leicester Tigers, 72 caps) 23. Max Malins (Bristol Bears, 3 caps)
