James Lowe will make his first start of the 2022 Guinness Six Nations and Michael Lowry will make his Test debut when Ireland host Italy on Sunday.
Lowe, who has become such a key weapon on the wing under Andy Farrell, missed the first two matches of the Championship with a hamstring injury.
But head coach Farrell has wasted no time in promoting him to the starting XV now he is fully fit.
Lowe forms a back three with fellow winger Mack Hansen, who moves from left to right, and full-back Lowry, who has had an outstanding season for club side Ulster.
Hugo Keenan and Andrew Conway drop out and are part of six Ireland changes, with Joey Carbery keeping his place at fly-half despite Johnny Sexton declaring himself fit this week.
Sexton is on the bench, while flanker Peter O’Mahony makes his first start of the campaign and captains Ireland from the blindside.
Caelan Doris, who started at No.6 against France, switches to No.8 to replace Jack Conan – who drops to the bench – while Leinster’s Ryan Baird replaces James Ryan at second row.
Hooker Dan Sheehan is set for his first Ireland start and replaces Ronan Kelleher, with Rob Herring promoted to the bench, while the final change sees centre Robbie Henshaw start ahead of Bundee Aki.
Ireland team to face Italy:
15. Michael Lowry14. Mack Hansen13. Garry Ringrose12. Robbie Henshaw11. James Lowe10. Joey Carbery9. Jamison Gibson Park
1. Andrew Porter2. Dan Sheehan3. Tadhg Furlong4. Tadhg Beirne5. Ryan Baird6. Peter O’Mahony CAPTAIN7. Josh van der Flier8. Caelan Doris
16. Rob Herring17. Dave Kilcoyne18. Finlay Bealham19. Kieran Treadwell20. Jack Conan21. Craig Casey22. Johnny Sexton23. James Hume.