Jack Nowell and Ben Moon come into the England starting XV as Eddie Jones makes just two injury-enforced changes for their Guinness Six Nations clash with Wales on Saturday.
With Mako Vunipola and Chris Ashton both out injured, the Exeter Chiefs duo of Nowell and Moon come in at right wing and loosehead prop respectively.
There are also changes on the bench as Joe Cokanasiga and Brad Shields both come into the matchday 23 for the first time this Championship.
And in the battle of the two unbeaten sides left in this year’s Championship, Jones is confident in the squad he has selected to head to Principality Stadium.
Jones said: “Ben Moon will start and Ellis Genge will finish so we will get a great 80 minutes out of those two. It is disappointing to lose a player of the calibre of Mako Vunipola but we have two very good players who will do a great job for us.
“Jack Nowell will start and Joe Cokanasiga will come onto the bench. As we saw in the autumn, Joe is a player of great potential so we are looking forward to him adding to the squad.
“Brad Shields comes in for Nathan Hughes as a finisher as we just feel like it is going to be a high work-rate game.”
Wales are on a record-equalling Test run of 11 consecutive wins while England are top of the standings after two bonus-point wins from two.
England have won the last five Championship meetings between the two sides however, and Jones cannot wait to sample what Principality Stadium has to offer.
He added: “England and Wales is always a big game. Intense rivals and there is the historical context to it, but for us it is our most important game because it is our next game and that is how we are treating it.
“Whenever you play against a Warren Gatland side you are playing against a side that is going to be very physical on the gain line. They are always very fit so you have to make sure you win the gain line and then find opportunities of where you are going to attack them.
“Their players are full of emotion and it’s the biggest game they are going to play in their lives. We have had a good week just focussing on ourselves and focussing on getting our preparation right.”
England starting XV 15 Elliot Daly (Wasps) 14 Jack Nowell (Exeter Chiefs) 13 Henry Slade (Exeter Chiefs) 12 Manu Tuilagi (Leicester Tigers) 11 Jonny May (Leicester Tigers) 10 Owen Farrell (Saracens) (captain) 9 Ben Youngs (Leicester Tigers) 1 Ben Moon (Exeter Chiefs) 2 Jamie George (Saracens) 3 Kyle Sinckler (Harlequins) 4 Courtney Lawes (Northampton Saints) 5 George Kruis (Saracens) 6 Mark Wilson (Newcastle Falcons) 7 Tom Curry (Sale Sharks) 8 Billy Vunipola (Saracens) Replacements 16 Luke Cowan-Dickie (Exeter Chiefs) 17 Ellis Genge (Leicester Tigers) 18 Harry Williams (Exeter Chiefs) 19 Joe Launchbury (Wasps) 20 Brad Shields (Wasps) 21 Dan Robson (Wasps) 22 George Ford (Leicester Tigers) 23 Joe Cokanasiga (Bath Rugby)