Meanwhile, Winnett's uncapped clubmate, back rower Alex Mann, has been named on the bench for Sunday's match in Cardiff (16:45 GMT, live on BBC and S4C).
The duo have both featured together for Wales U20 before. With a further emphasis on youth, Exeter Chiefs' Dafydd Jenkins becomes Wales' second youngest captain of all time at just 21 years of age.
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Wales team 15. Cameron Winnett (Cardiff Rugby - uncapped) 14. Josh Adams (Cardiff Rugby - 54 caps) 13. Owen Watkin (Ospreys - 36 caps) 12. Nick Tompkins (Saracens - 32 caps) 11. Rio Dyer (Dragons - 14 caps) 10. Sam Costelow (Scarlets – 8 caps) 9. Gareth Davies (Scarlets – 74 caps) 1. Corey Domachowski (Cardiff Rugby - 6 caps) 2. Ryan Elias (Scarlets – 38 caps) 3. Leon Brown (Dragons – 23 caps) 4. Dafydd Jenkins (c) (Exeter Chiefs - 12 caps) 5. Adam Beard (Ospreys – 51 caps) 6. James Botham (Cardiff Rugby – 9 caps) 7. Tommy Reffell (Leicester Tigers – 13 caps) 8. Aaron Wainwright (Dragons – 43 caps)
Replacements 16. Elliot Dee (Dragons – 46 caps) 17. Kemsley Mathias (Scarlets – 1 cap) 18. Keiron Assiratti (Cardiff Rugby – 2 caps) 19. Teddy Williams (Cardiff Rugby – 1 cap) 20. Alex Mann (Cardiff Rugby – uncapped) 21. Tomos Williams (Cardiff Rugby – 53 caps) 22. Ioan Lloyd (Scarlets – 2 caps) 23. Mason Grady (Cardiff Rugby – 6 caps)
