Toulouse's Kinghorn has recovered from the injury that ruled him out of rounds one and two of the Championship to take his place at fullback.
The 27-year-old mostly deputised for Stuart Hogg at 15 in last year's Guinness Men's SIx Nations, before bursting to prominence at fly-half in a hat-trick performance in the closing round against Italy.
Following an agonising loss to France in round two, Scotland are now setting their sights on a fifth win in seven Calcutta Cup meetings with England. Victory in Edinburgh would equal their longest winning streak of four matches in this fixture, which was achieved between 1893-1896.
Scotland team to face England (16:45, live on BBC)
15. Blair Kinghorn 14. Kyle Steyn 13. Huw Jones 12. Sione Tuipulotu - Vice-Captain 11. Duhan van der Merwe 10. Finn Russell – Co-Captain 9. Ben White 1. Pierre Schoeman 2. George Turner 3. Zander Fagerson 4. Grant Gilchrist 5. Scott Cummings 6. Jamie Ritchie 7. Rory Darge – Co-Captain 8. Jack Dempsey
Replacements
16. Ewan Ashman 17. Alec Hepburn 18. Elliot Millar-Mills 19. Sam Skinner 20. Andy Christie 21. George Horne 22. Ben Healy 23. Cameron Redpath
