Sam Underhill and Iain Henderson have been recalled back to their respective squads ahead of the crucial England v Ireland Guinness Six Nations fixture at Twickenham on Saturday.
Both teams know that they must win at the weekend if they are to remain in with a chance of winning the 2022 Guinness Six Nations heading into the final round of fixtures.
25-year-old Underhill returns to the England set up for the first time since the Autumn Nations Series after injury and illness and provides crucial reinforcements to England’s back row.
Alex Dombrandt, who started at No.8 in the 23-19 win over Wales in Round 3, tested positive for Covid-19 on Friday while flanker Tom Curry came off at half-time against Wales after failing a head injury assessment, though both will hope to be in contention to face Ireland.
Underhill returns to the squad alongside hooker Nic Dolly, scrum-half Alex Mitchell and uncapped duo Orlando Bailey and Luke Northmore.
Eddie Jones will be without Raffi Quirke after the scrum-half suffered a concussion for Sale Sharks at the weekend, while Manu Tuilagi has not returned to the squad after pulling out of the team to face Wales with a hamstring injury.
Meanwhile, Ireland will be able to call on Henderson after the forward was recalled by Andy Farrell.
The Ulster second-row was unavailable for the match against Italy due to Covid-19 but returns having completed 80 minutes for his province against Cardiff at the weekend.
It offers a further boost to an Ireland pack that has already impressed this Championship with strong performances from the likes of Ryan Baird and Josh van der Flier.
Henderson returns alongside Jack Carty, Dave Heffernan, Craig Casey, Gavin Coombes and Robert Baloucoune, James Hume, and Nick Timoney as Farrell shapes his squad ahead of the trip to Twickenham.
Jordan Larmour will not be available for selection due to a hip injury but there is a first call-up for prop Jeremy Loughman.