Both sides go into the match on the back of round two victories in the Guinness Women's Six Nations - Italy's against Ireland, and France's against Scotland.
Scrum-half Sofia Stefan - who will win her 85th cap at the Stade Jean Bouin - captains the side in the absence of Elisa Giordano, who has a calf injury.
Other absentees include back Francesca Sgorbini and prop Silvia Turani.
Italy team to face France
15. Vittoria OSTUNI MINUZZI (Valsugana Rugby Padova, 30 caps); 14. Aura MUZZO (Villorba Rugby, 42 caps); 13. Beatrice RIGONI (Sale Sharks, 72 caps), 12. Emma STEVANIN (Valsugana Rugby Padova, 13 caps); 11. Alyssa D'INCÀ (Villorba Rugby, 23 caps); 10. Veronica MADIA (Grenoble Amazones, 48 caps), 9. Sofia STEFAN (Capitana, Valsugana Rugby Padova, 84 caps); 1. Gaia MARIS (ASM Romagnat Rugby, 27 caps), 2. Vittoria VECCHINI (Valsugana Rugby Padova, 23 caps), 3. Sara SEYE (Ealing Trailfinders, 20 caps) 8. Ilaria ARRIGHETTI (Stade Rennais, 58 caps), 4. Valeria FEDRIGHI (Stade Toulousain, 52 caps), 5. Giordana DUCA (Valsugana Rugby Padova, 45 caps), 6. Sara TOUNESI (Sale Sharks, 37 caps), 7. Isabella LOCATELLI (Rugby Colorno, 48 caps)
Replacements
16. Laura GURIOLI (Villorba Rugby, 9 caps), 17. Emanuela STECCA (Villorba Rugby, 9 caps), 18. Lucia GAI (Valsugana Rugby Padova, 97 caps), 19. Alessia PILANI (Rugby Colorno, 6 caps), 20. Beatrice VERONESE (Valsugana Rugby Padova, 17 caps), 21. Alessandra FRANGIPANI (Villorba Rugby, 7 caps), 22. Francesca GRANZOTTO (Unione Rugby Capitolina. 9 caps), 23. Beatrice CAPOMAGGI (Villorba Rugby, 12 caps)
